The pdoomers have a generally great point that, if superintelligence kills us (they'd say "when", not "if"), we won't be able to predict the mechanism of doom. It'd be like asking ants to predict that the borax they're carrying back to the hive for their queen to feast on will disrupt their digestion and kill them.
I'd also argue that the biggest threat from ASI is what I've heard Roman Yampolskiy label as "ikigai-doom"; that AI could become so much better than humans at all the things humans do, that even in the best case humanity is left with no purpose, not even to pursue creativity because the AI will be so much better at even creative acts; and in the worst case, our government and societal structure can't adapt and millions become unemployed. There's no way to build a safety mechanism against this threat because the threat is intrinsic to all the good things ASI will give us. The only winning move is to not play.