Evolution also "tries" to save energy anywhere possible, so spending energy on the synthesis of endogenous ligands, which eventually will be discarded, seems a bit redundant. There is also a theorem in evolutionary game theory, that probability that natural selection will allow an organism to see reality as it is (=the truth) is exactly zero, as it's enough to make it just "good enough". I was arguing about that with Gemini, and it agreed with me. My point is that "evolution" is just a tool (like ChatGPT) with it's own instrumentally limited pool of empirical data (80% of which was also obtained from macroscopic enough observations rather than reverse engineering or experimentation) to build upon.
I actually want to apply one EE concept, which has some experimental basis. The reason why I am digging this, is that I am searching for some possible explanations of a couple of dozens of experimental studies in bioelectrics/magnetics I found. (though won't discuss in depth on a public forum)