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Comment by j0hnyl | Hacker News Reader

I'm very skeptical that 1.25mg of CBD alone could have any impact on sleep outside of placebo.

At least for me and for some others I have met, we have an immense sensitivity to cannabinoids. I will actually get a decent buzz from CBD gummies that most people feel absolutely nothing from, even if they eat the whole bag. I cannot smoke any THC flower because it's all way to strong, and the only way I can consume THC is cutting up gummies into small pieces.

OMG!!!

For YEARS I've wondered why I get a buzz from CBD, when it's "not psychoactive".

It's incredibly affirming to know I'm not the only one.

As for flower, I feel "full" while others have more, although I'll feel like more before they do (as they've had like half as much again as me).

The big thing is different ppl seem to have different sensitivities to different cannabinoids. This probably means something about the relative densities of CB1 vs CB2 receptors

I'm not; this also works for me better than anything else I've tried.

Don't ruin their placebo by telling them!

One of the cool things about placebo effect is that it can work even if you know it's a placebo!

I think some work measurably better when you know it's a placebo and not something that may or may not work.

I've long considered manufacturing and selling something that does that, but I think the homeopathists have the market sewn up.

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