"Canagliflozin extended the lifespan of mice with premature aging even when treatment was started in middle age."

Canagliflozin is an existing prescription drug, with possible side-effects: https://www.mayoclinic.org/drugs-supplements/canagliflozin-o...

A previous study showed a gender effect: Canagliflozin extends life span in genetically heterogeneous male (14%) but not female mice (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710304/)