SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

"Canagliflozin extended the lifespan of mice with premature aging even when treatment was started in middle age."

Canagliflozin is an existing prescription drug, with possible side-effects: https://www.mayoclinic.org/drugs-supplements/canagliflozin-o...

A previous study showed a gender effect: Canagliflozin extends life span in genetically heterogeneous male (14%) but not female mice (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710304/)