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lol The sample size in induced pluripotent stem cell research is often like this because of how laborious it is, and cutting edge. Moroever, while the parent sample is small, it doesn't mean that number of samples per individual is small.

I haven't read the paper yet, but if its like what our team is doing, we take blood, and turn the cells there into neurons, then organoids.

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I can see that the research makes many organoid samples (4000+) mentioned in the paper. This is good to validate the organoid results are consistent.

however, then correlating the consistent organoid attributes back to attributes of a small parent sample group is weaker on small sample groups than larger ones. here the parent group is tiny… and the severe ASD sufferers is even smaller (n=2 or 3 by my understanding)

great foundational research! but surely larger group sizes are required before correlation is confirmed

Absolutely!

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