If it didn't occur in nature where evolution honed both its existence and human's tolerance to it, then don't consume/use it.
After so many years, I simply can't count how many times "science" has brought us some new food, ingredient, or chemical, which passed all security measures, only to find later it causes or contributes noticeably to some horrible outcome. And I'm perfectly fine not attributing malice. My experience tells me we're quite good at doing the wrong thing while thinking we're doing the right thing. Although, given the current economic climate, malice is probably just as valid.