I hoped that proffering this idea here would be fruitful and prosperous, and already I am satisfied. Thanks.
I fooled around with Inform for a while a few years back, it's like writing an adventure game within the natural language interpreter itself, complete with all the interpreter's quirks and deficiencies. Battling against this was a fun challenge and a game in itself. Some people are productive in it, somehow.
That echoes my experience as well. I think it may be easier for those who have not had formal training in a traditional programming language, who happen to also be especially detail-oriented writers.
The target machine it's the same. If any, glulx could do more stuff.