I know they mainly present results on deep learning/neural network training and optimization, but I wonder how easy it would be to use the same optimization framework for other classes of hard or large optimization problems. I was also curious about this when I saw posts about Extropic (https://www.extropic.ai/) stuff for the first time.

I tried looking into any public info on their website about APIs or software stack to see what's possible beyond NN stuff to model other optimization problems. It looks like that's not shared publicly yet.

There are certainly many NP-hard and large combinatorial or analytical optimization problems still out there that are worth being able to tackle with new technology. Personally, I care about problems in EDA and semiconductor design. Adiabatic quantum computing was one technology with the promise of solving optimization problems (and quantum computing is still playing out with only small-scale solutions at the moment). Hoping that these new "thermodynamic computing" startups also might provide some cool technology to explore these problems with.