At some point, given the universe's expansion, galaxies will be moving away so fast that the observable universe will be just one galaxy. Already, the effective rate from galaxies far away is actually faster than the speed of light. Even at light speeds, we cannot reach 94% of them as we would never catch up if we left today. In cosmic scales of many billions of years, observers on every galaxy will eventually think that their galaxy is the only one that has ever existed.
Large distance and time scales are rather gloomy.