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I wonder if there’s data to assert what’s more dangerous in the long term:

Stay absolutely seated and fastened for the whole flight;

VS.

Stay absolutely seated and fastened for the whole flight with a few breaks to walk around and stretch your legs.

PS: Yes, sitting without fastening your seatbelt is just plain stupid.

Instead of just walking around, drink lots of water and then go to the bathroom, and rinse and repeat (it also works if you don't enjoy your job office).

The alternative is to do the standard sitting exercises intended to avoid DVT.

eg wiggle your toes, flex your leg muscles, rock your feet, etc.

All you need do is avoid pinch points which block blood flow.

These are routinely taught to solders on point duty, pilots on long flights, patients confined to bed,etc.

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