I always hesitate a little bit when I open a pdf, specially when it is one on malware
You should still have some kind of comprehensive security solution in place, particularly for a business environment, but use of non-standard software is an effective fail-safe for when your "real" security craps out on you (as it inevitably will).
[1]http://blogs.adobe.com/asset/2010/10/inside-adobe-reader-pro...
[2]http://dev.chromium.org/developers/design-documents/sandbox
[3]http://blogs.msdn.com/b/david_leblanc/archive/2007/07/27/pra...