The risk with these if they are sufficiently large would be an explosion on impact. This is dealt with by placing a thin barrier in front of the vehicle. The particle explodes on impact with the barrier, cutting a small hole. The debris shoots forward, spreading, and is absorbed on a shield. At 0.01 c, a 1 microgram particle deposits 450 joules of energy. This is called a "Whipple Shield".

If necessary, parts of this system could be replaced during the journey.