Put tight controls in place. You can make it extremely difficult to bypass. You could have a recovery mode like Android and bury the setting in there. I think that makes it sufficiently hard that you don't have to worry about a grandma being tricked into rebooting her phone while holding down a specific button combination and then navigating through a bunch of arcane menus without touch controls to enable side loading. But its enough that someone that is technically inclined and who wants that control over their device can have it.
The solution to the grandmother scenarios is to have a trusted relative that works closely with them, who they trust to copilot or handle completely all business dealings. If that's not possible, then they're at risk whether they have an iphone or android.