In my experience the metaphor doesn't stretch to RIAs. My start-up's main application is precisely one of those "RIA that pretends to behave like a desktop app", and thanks to Flex we've been able to get a good enough approximation. Result? Our users don't feel uncomfortable about it (although we have had the odd user who seemed to expect that everything would be instant even though it was a web-app). On the contrary, our users love it, and have commented on it positively many times.
I guess people care less about that last 1% when looking at a web application than when looking at a humanoid robot. Which means stretching the metaphor in this direction doesn't quite work.