At first glance, Hono seems like the most standards-compatible framework.

> It works on any JavaScript runtime: Cloudflare Workers, Fastly Compute, Deno, Bun, Vercel, AWS Lambda, Lambda@Edge, and Node.js.

Not sure it counts as “any JS runtime” if it does not work in browser (e.g., worker context), but judging by the rest of the docs it might work there, too.