RE: never listening to any 5by5 podcasts–I listened to The Talk Show a few times. Maybe it's because I'm used to the dogma of professional broadcasting, but I don't think you've missed out unless you like hearing a couple of guys pause a hell of a lot during an awkward conversation. Almost every episode I heard started with an entirely charmless "Uh, hello?" "Uh is this on?" scenario.
I guess part of the appeal was that it was folksy and just a conversation.