Safer tries to suggest that Thiel is advocating against college for everybody, or any field. What I take from Thiel's stance is that college has become less of a place of learning, and more of an inefficient credentialing mechanism.
Safer makes the interesting point that most startups will fail, but what he seems to miss (or Thiel doesn't point out): Thiel Fellows also have a credential of a kind, and even in failure, an extremely lucrative one.