The only intervention known to work reliably was bariatric surgery until stuff like Ozempic showed up recently.
The only intervention known to work reliably was bariatric surgery until stuff like Ozempic showed up recently.
Lots of people aren't overweight, so apparently it works on a lot of people. Eat less is perfectly fine advice, it might not work for everyone but it works for everyone who can keep it. Some need additional help after hearing that advice to ensure they actually eat less, others are fine with just that.
Recent commercialization and buzz is definitely new and there have been new formulations of course.
It is quite remarkable that people might think simply telling people to "lose weight" will work still, in this day and age.
Type 2 is the exact opposite. Your cells are saturated with glucose and your body literally can't produce any more insulin to stuff that glucose away. Giving insulin just forces the excess blood glucose into tissue and causes additional fat gain. The additional fat gain makes Type 2 worse. Weight loss is the treatment for Type 2.
We've kind of known this since 1915 when Type 2 was treated with fasting. Right up until insulin was discovered. [1, 2, 3]
That's why GLP-1/GIPs work for diabetes. They make you not hungry, so you don't eat, so you lose weight, and presto, no more insulin resistance.
> [...] we now understand that people with type 2 diabetes who lose significant weight and improve other factors related to diabetes can achieve remission. [3]
Fun fact.
[1] https://www.endocrine.org/news-and-advocacy/news-room/2022/i...
[2] https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
[3] https://www.niddk.nih.gov/health-information/professionals/d...
Someone genuinely worried about obesity wasting doctors' time should be all for stuff like Ozempic.