I find modern IDA pro to be pretty inaccessible, same with Ghidra (though I only tried that one on Mac, and the Windows version is apparently somewhat better).
Ghidra has a “headless” mode where it will just run without the UI.
Or have you tried Binary Ninja? Its UI is simpler and a bit more primitive, but it is designed more programmatic analysis, less manual/interactive usage. It’s GUI is more for debugging scripts, not so much for manual reversing.
Programmatic analysis can be powerful for automated taint analysis and such.
anyway, it was IDA Pro, and they had spent some upfront time on tuning the layout to optimize their flow. I do not remember specifically but yes their IDA looked very different than the default setup.
Where I found a lot of bugs is when it comes to supporting web standards like mathML, and this is where I will usually switch to windows since the screen reader tends to be more flexible, and you have a lot more software focused on assistive tech.
previously macos just worked way better given that the apps were developed with apple's framework and polish, and accessibility was part of that