In the ARPG/Diablo genre, Path of Exile is one of the worst offenders. Each character progresses through a 2D locally-connected graph of over 1300 passive skill nodes, of which you only get to pick about 100, where the "undo" action is expensive or impossible.

That said, the sheer amount of options leads to a class of expert players and build-makers that normal players can rely on. I just wish the game itself provided more tools for navigating it (like an ingame build-guide system).