(Cloudflare Workers tech lead here.)
I disagree about V8 not being optimized for edge environments. The needs of a browser are actually very much aligned with needs of edge, namely secure sandboxing, extremely fast startup, and an extreme commitment to backwards compatibility (important so that all apps can always run on a single runtime version).
Additionally, V8 is just much better at running JavaScript than you can hope to achieve in a Wasm-based JS implementation. And JavaScript is the most popular web development language (even server-side).
> On it's current form it can add up from ~2-5ms in startup just by initializing an Isolate
So, you and I seemingly have a disagreement on what "cold start" means. Wasmer advertises its own "cold start" time to be 50ns. This is only remotely possible if the application is already loaded in memory and ready to go before the request arrives. In my mind, this is not a "cold start". If the application is already loaded, then it's a "warm start". I haven't spent the time to benchmark our warm start time (TBH I'm a little unclear on what, exactly, is counted in this measurement), but if the app is already loaded, we can complete whole requests in a matter of microseconds, so the 5ms number isn't the correct comparison.
To me, "cold start" time is the time to load an application, without prior knowledge of what application will be needed. That means it includes the time to fetch the application code from storage. For a small application, we get around 5ms.
Note that the time to initialize an isolate isn't actually on the critical path to cold start, since we can pre-initialize isolates and have them ready to go before knowing what application they will run. That said, we haven't implemented this optimization historically, since the benefit would be relatively small.
However, with Pyodide this changes a bit. We can pre-initialize Pyodide isolates, before we know which Python app needs to run. Again, this isn't implemented yet, but we expect the benefits to be much larger than with plain JS isolates, so we plan to do so.
> Ideally you should be able to pin any Python version that you want to use in your app:
Minimizing application size is really essential to making edge compute inexpensive -- to run every one of two million developers' applications in every of our hundreds of locations at a reasonable price, we need to be able to run thousands of apps simultaneously on each machine. If each one bundles its entire language runtime, that's not gonna fit. That does mean that many applications have to agree to use the same versions of common runtime libraries, so that they can share the same copies of that code. The goal is to keep most updates to Pyodide backwards-compatible so that we can just keep everyone on the latest version. When incompatible changes must be made, we'll have to load multiple versions per machine, but that's still better than one copy per app.