> So-called forever chemicals like per- and polyfluoroalkyl substances, better known as PFAS, have been linked to other cancers and could also be driving some of the increase in early-onset colorectal cancer.
I think, it's also worth considering the fallout of the AIDS scare messing with statistics here. PrEP, education on and treatment options for HIV may have caused people (including heterosexual) to use less protection in recent years, unfortunately, since other STIs are less scary and stigmatized. I doubt rates of oral and anal sex have increased that much.
Also plastic usage has massively increased compared to the 50s and 60s. Especially things like plastic fiber fast-fashion clothing shedding microplastic particles during wear and washing. Then there is synthetic polymers as cosmetic and personal care ingredients. Plastic bottle and pipe usage increased too, I think.