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You will almost certainly never see at home versions of these drugs, the risk profile is far too great. Roughly 13% of strokes are hemorrhagic and that's just the first and most obvious hazard.

If I remember correctly, part of the goal here is to gain a bit of time while the patient gets to the ER. I’m no expert but as you seem to have alluded to, the risk profile of alteplase/tenecteplase doesn’t seem to be well suited to an autoinjector with “if in doubt, use it and call the ambulance” instructions.

yeah but then it'll have to compete w/ aspirin/clopidogrel...meaning they're limited on the margins they can set for the med, and injectables tend to be pricey...

None of these works nearly as well as angioplasty

yes but tpa/tnk is way closer to an angioplasty than selatogrel...