I wonder if it's better to have a lot of small hits or a few big hits and many misses in regard to replication. If the studies which have the greatest implications replicate, then maybe many misses is not that bad.
Unfortunately the reality is that the more interesting and quotable the result is, the less likely it is to replicate. So replication problems most strongly hit things that seem like they should have the greatest implications.
Kind of a "worst of all worlds" scenario.
Some believe the resulting garbage. And wind up with weird ideas.
Others use that garbage to justify throwing out everything that scientists say. And then double down on random conspiracy theories, denialism, and pseudoscience.
I wish there was a solution to this. But everyone is actually following their incentives here. :-(