Meaningfully competing with Photoshop & co involves breaking the lock-in (nearly impossible) and being much better use-case-wise. It's been done in certain niches where Photoshop is bad/mediocre/stagnates, like digital painting, but for general purpose suites like Affinity it means they have to be better at most things, which they just don't seem to be capable of.
If you are print designer than Publisher and Designer got to a point where they actually are better at many if not most fundamental things (speed, stability, ux of features, format support).
The main thing that has been keeping Affinity from adoption has been networking effects (adobe is in all companies and gets taught at schools).
Affinity is this close to turning this. Basically everyone has been waiting for them to allow third party plugins/scripting and the whole print industry would start to jump real fast.
Actually I take it back, Acrobat is probably #1
Heck, I am frustrated that Canva didn’t have a layers panel, and now that they do, that it doesn’t behave the way I expect and I can’t pull it up easily… or that Canva makes it impossible to ensure assets match when searching for a matching sequence or set of templates. Or all the ways I can’t just do the thing I’m thinking of by right clicking or modifying layers or something. Canva itself is an exercise in frustration for power users. Affinity ain’t perfect either. Great matchup, really.
Text rendering algorithms are quite known quantity and lifted from LaTeX. Indesign has paragraph (multi-line) composer which in latex equivalent is microtype package. Affinity doesn't have that but paragraph composer is not really used that much in professional setting because when you do final manual fixes/adjustment of typography then with paragraph composer your changes could affect previous changes in paragraph (so people go by line by line). Paradoxically paragraph composer is pretty good for quickly getting OK enough results especially in more budget/non-pro setting.
Other than that i don't think the typography output (for print) is different I've seen some tests and it seems kinda exactly the same. Affinity might render type on screen a bit differently but the output is solid. I was more afraid of the quality of .pdf itself but even highend offset printers didn't see a difference/complained.
After Effects simplicity compared to the hellscape that can be node-based VG work. I mean, the programmer in me loves nodes, I even used MaxMSP frequently… and Origami. But the simplicity of After Effects is really nice and it has like every plugin in existence.
Don’t get me wrong, I use DaVinci with the quick editor and have considered buying other gear to make it work better, but… it’s really kinda a jack-of-all-trades, master-of-color-grading app. There’s a lot still to wish for.