This isn't really a startup kinda business. It costs something like $10b to build a new fab.
The equipment and facilities required for cutting edge fabs are very expensive.
However, it isn't as clear if the same applies to semiconductors, since even a bit of dust is indeed a serious problem for producing a chip where the transistors are much smaller than most dust. Until very recently there were no blank checks, every improvement required mostly private investment, so it's less likely that the inefficiencies are intentional.
Who in their right mind would invest $10b just to build the manufacturing capability without having a well established product? And if you have a well established product are you still a startup?