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It's easier and more plausible than a rat poison that doesn't hurt people; harder and less plausible than an antibiotic that doesn't hurt people; ultimately the proof is in the pudding.

Personally I would not try this in a long lasting formulation, only something oral that washes out completely in a few hours, unless it had been on the market for quite a long time

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People also believed that pesticides like Roundup only affect insects. However, after a few decades it is becoming clearer that there is a link with Parkinson's.

See e.g.: https://parkinsonscare.org.uk/pesticides-and-herbicides/

I've also been suspicious of the long lasting topical antiparasitics for cats - The drugs are targeted to glutamate gated chloride channels which mammals don't have, but, off target binding to excitatory glutamate receptors (AMPA/NMDA) is still possible in theory and likely in practice given the adverse/overdose effect is seizures. I'd like to think seizurey behavior should be obvious, but subacute excitotoxicity is harder to characterize - usually is only mentioned in the context of cognitive damage from chronic subacute seizures.

But on the other hand it's good at keeping the ticks from attaching to my cat so they can all move on to me as I sleep, totally worth it

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