I’m surprised this article wasn’t about Metformin, something gwern has written about[0] and has some popularity in the entire nootropic circle of people that I know.
"probably also offers only a constant reduction in risk without decreasing the acceleration of risk, if for no other reason than hundreds of millions of people have taken metformin over the past century yet no gerontologist has ever noticed a massive overrepresentation of diabetics among centenarians"
Ummm, and also WW2 planes that made it back to the base had damage in the least crucial areas.
As best I can tell the smartest people hold more true beliefs and have fewer blind spots which has me leaning towards the latter explanation. But as this is purely based on my subjective observations it’s possible that this is merely the result of my own biases.