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Comment by gumby | Hacker News Reader

The interesting part of this is that seratonin is a neurotransmitter so it's interesting to see it potentially relevant in a different organ system.

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The gut microbiome is coming out as linked to so much more in the body that we ever imagined previously. My theory is that I got RA due to depression and horrible diet (because doctors can't exactly tell). Lack of serotonin threw the immune system off.

Seperately, issues with dopamine change how the brain perceives and flags pain signals. In someone with a deficiency and suffering from chronic pain the two are linked.

Yes I think this pattern will get much clearer in the near future. We already see these links with chronic illness, depression, etc and gut dysbiosis. One thing I wouldn’t count out is the effect of lingering virus or viral antigens causing regular immune system stimulation leading to various unexplained illnesses to varying degrees. They also can contribute heavily to gut dysbiosis which may be linked with serotonin production and other things. Knowing how bacteria plays together is one thing but we also need to understand how pathogens can affect our guts as well!

Yeah, low grade infection persisting was also a possibility. As well as dysregulation from nicotine/alcohol/cannabis overuse and lack of meaningful reliable social interaction. The full college experience in short. Up to that point I thought the most likely and dangerous ailments were from acute injury (which I was deft at avoiding during risky thrill-seeking behavior). But I believe I had it completely backwards.

This might be interesting to you: https://www.acpjournals.org/doi/10.7326/M23-1831

It is suggested that many viruses can do this.

I appreciate it. I'm thankful the lifestyle guidelines are improving in adoption rates and quality. What I mean is that more and more diet and exercise (and meditation) are as key as any highly successful targeted drug. The idea is to do all simultaneously. https://en.wikipedia.org/wiki/Biopsychosocial_model?wprov=sf...

There are studies (multi-generational long-term) telling us that positive/meaningful social experience is one of if not the greatest factor in affecting healthspan.

what is RA?

Rheumatoid arthritis, an autoimmune condition that affects joints and/or organs by inflammation.

People taking SSRIs are familiar with it having effects in other organs, lolsob…in the human gut excess serotonin induces diarrhea and vomiting

Somehow I’d never encountered “lolsob” before — how useful! Thanks.

Everything in biology is interconnected random chance use of the same blocks that worked over a long enough time.

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