In 2004 I started using WordPress and helping in the support forums. My site url was posted many many times all over the place as I wrote and hosted the first WP Support guides.
Many people began experiencing comment spam, and pre-Akismet there were many solutions from a tarpit to moderation word lists. Curiously though I got no spam. Zero. Eventually, after seeing the size of the problem hitting other sites I checked the access logs.
My blog was at http://example.com/T2/
The logs showed I was being battered by spam, but they were hitting http://example.com/t2
That uppercase letter had been inadvertently saving me for months. Of course the spammers wised up but I found it amusing at the time.