Are they actually responsible for the observed activity, or do they merely trigger some ‘flushing’ mechanism inherent to the cells? Or, are the waves a result of that process?
"The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves."
Sounds like unsync'd brain waves, (being awake) impedes cerebrospinal fluid flow through the brain.
When asleep, neurons sync their action potentials, acting like a ionized fluid pump, moving old dirty cerebrospinal fluid out, and allowing new, clean in.
Interestingly, when they synthesize that type of ionization using other means, they saw the same increase in fluid movement.
This is my best attempt at translating. Hopefully within 1-2 football fields. The author leaves choice of American or the rest of the world to the reader to decide.
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Well, thats basically the trope of every Cybernetic design, with the connectors comming out the back of head/spine...
Like a continual wash which keeps you in this suspended hyper-aware, but calm, rested and focused mental state.
This is why cyborgs have such incredible reflexes.
Most fascinating video I’ve seen in a long time.
Edit: If you haven’t seen it yet, I highly recommend checking it out https://youtu.be/7BGtVJ3lBdE
If we can create/prevent blood-brain-barrier-"Portals" as it were, via ultrasound - and do so like we do with the gamma knife but with sound waves, it would be more harmonious with our nature. (3/6/9 tesla rhythms and all that)
and was just thinking about the vid you had, and how they are using the ultrasound intersections "at the blood brain barrier
Where exactly is this intersection occurring?
Is it poking a hole in something for the plaque to 'flow through' via the cereberal flush?
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Ah I have my answer::
The transiant gap created by FUS will last a few hours...
So - here is where a few LLM ideas come to mind - as the gap allows for the flow of the enzymes through for a bit before they heal - what is the optimal location for placing the FUS pulses?
How many FUS pulses required to create the gap is unclear, as is exactly how long it takes for the enzyme flush - however, there is currently (mostly?) single point systems, but multi-point systems are being tested. What would be interesting to determine is if there could be a spatial pattern for placing the gaps, assuming you have a multi-point FUS system, imagine creating (N) FUS gaps simultaniously in a pattern which followed the natural flow of the enzyme flush - such that if the cereberal flush is flowing in a clockwise fashion - openening FUS gaps in accordance with the direction and timing of the enzyme flush's frequency. directed flow FUS animation.
It seems you dont have to explicitly open a gap with a FUS pulse - so can "massage" behavior such that you can direct flow? I guess only depending on the frequency with which you can aim and fire FUS pulses - but if you have multiple FUS sources? you can 'kite' the flow in...
which reinforces this: "In the context of Alzheimer’s disease, post-FUS tracer enhancement phenomena suggest the existence of a brain-wide perivenous fluid efflux pathway in humans4. This could potentially facilitate the drainage of harmful substances
I wonder what the energy consumption per pulse, how many pulses per gap, how many gaps per hour.
https://www.elcaminohealth.org/news/el-camino-hospital-purch...
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But what would be really interesting is the marriage of a multi point FUS system layered on top of a cyberknife where as the cyberknife uses xrays to track the position of the prostate in order to determing the location of the point its 'knifing' - if you can massage points into position using FUS - maybe a multi-point FUS can hold a prostates target in position in sync with the cyberknifes 'knifing' and validation via xrays?
-- ala:
Focused Ultrasound (FUS) and the Blood-Brain Barrier (BBB): FUS has been shown to disrupt the BBB in a noninvasive, safe, and targeted manner1. The mechanical effects of FUS, namely cavitation, are thought to be the principle cause behind this BBB disruption1. This method of BBB disruption – FUS with microbubbles – has had very promising results1.
CyberKnife and Prostate Treatment: The CyberKnife System uses advanced technologies to track tumors anywhere in the body, while its unique robotic design keeps the radiation on target even while the tumor moves2. Before delivering the radiation beam, the CyberKnife System verifies the exact tumor position then adjusts the robot to precisely target the tumor2. This system is particularly effective for treating prostate cancer345.
Potential Combination of FUS and CyberKnife: In theory, a multi-point FUS system could potentially be used to “hold” a prostate target in position, working in sync with the CyberKnife’s tracking and ‘knifing’. This could potentially enhance the precision of the treatment, as the FUS system could help ensure the prostate remains in the optimal position for the CyberKnife treatment.
It is pretty grueling how bad it feels to not sleep so a cap like this would at least make it so the build up doesn't kill you from over collecting old fluid excessively.
This line is the money shot. An action potential is the variable electrical charge of a neuron, and they maintain that charge by containing a certain concentration of ions relative to the surrounding cerebrospinal fluid. This paper proposes that neurons synchonise their charge state, which forces ions to flow in or out of the neurons in bulk, the movement of these ions causing the cerebrospinal fluid to move around, clearing out the accumulated debris.
If you look at the Goldstein-Katz equations you see that the conductivities play an as important role as the concentrations.
Most of the voltage change is driven by changes in conductivities and not concentration changes, the ion movements across the membrane should be negligible.
Off course you have the free ions outside the cells than diffuse in a field gradient.
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I tried to observe the phenomena yesterday again and couldn't observe it but it was very specifically this in the past: spherical orbs of white light expanding from a centre. There were many of these, and my perception was that the nature of this geometric expanding shape was healing. To describe it more clearly, many years ago I felt that the perfect geometric spherical nature of these expanding waves were designed to gently round off rough edges. To make an analogy, imagine kneading some play dough over and over again. When you use your hands to do so, every time your hands make contact with the play dough, the play dough changes shape slightly because of the contact between your hands and the play dough and it gets softer. Now apply this concept to the idea of energetic waves making contact and passing through the material substrate of the brain and the rest of the body (yes I observed the waves applying to more than just my mind). It was my physical and conscious perception that as the spherical waves emanated from some center, they gently readjusted the physical substrate that they passed through. And because there were so many of them in different spatial locations, this readjustment was incredibly refined.
I have no expertise in this area I’m just a dreamer :)
There are courses one can take where one learns this, like Art of Living and any other that follows the same traditions.
Yes, there's research on that, and new studies should absolutely gain from this study. Not entirely sure you'll observe the same effect, that depends on meditator, but you can fall asleep during practice.
I have over a decade experience with it, and have also participated on a study on breathing exercises and epigenetic effects from that versus blind control.
Replacing hours of sleep with hours of yogo or mediation seems like you are not gaining anything.
See it like exercising: you might think that spending time on exercising takes away time that you could spend on doing useful things. But it actually gives you better health, making you function better in your daily life. So it enables you to do things more efficiently. And you'll feel healthier, better, happier. So ultimately you gain from it.
However, the goal of meditation can be very diverse, since there are many different techniques, each with their own aims and side-effects. Generally, the main goal is often to calm the mind, make the body relax and let go of stress. There are many more benefits though, which you only realize when doing personal and experiencial practice over longer periods of time. It's not like the effects are the same for each person even, so it's more like a discovery process rather than do A, B, C techniques for X, Y, Z gains. However, there's a baseline of methods and general health, which is what it's usually used for. Very few people are suited to be munks or living in secluded communes like that. But it can be Very nice to be on a 1-2 week retreat now and then.
Of course that's a huge generality, I'd say it may be 1 out of 5 people like that in the US, but its the fact that it is not constrained to any particular demographic/background.
I wouldn't be surprised if the idea that it's completely useless because it can't be scientifically observed in a traditional sense is highly correlated with people who think that mental health issues aren't real in general.
Where's the evidence that yoga and meditation accomplish the effects of sleep and how strong is it?
https://www.artofliving.org/us-en/meditation/sleep/meditatio...
You don't really need studies for this when you can have experiential evidence through own practices, which is much more important for an individual than external studies.
Let's say my discretionary spending is 30% of my income, it goes up by a third, and I need to work 10% longer hours. Okay, so I adjust to a 44 hour work week and I get an extra 30+ hours of free time? Great!
it could be used in endurance/focused events. high stress relief, traumatic brain injury - like immediate induce afte cte event in foot ball
head trauma in car accident
ODs etc...
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When I was a baby, and I would get ill, my mom would calm me and put me to sleep - and I would sleep for an extended period and my mom would say that I would wake up fully well.
If this could be induced in infants going through trauma's such as a surgery, where inducing natural brain-flush instead of pumping a tiny body full of "medicine" this might be great for their long term mental development outside of having medicines in them when growing extremely fast.