I buy the semaglutide as a research peptide and manage my own dosing based on symptoms and ended up at 0.25mg per week which is a low dose but also makes it very cheap. I appear to be much more sensitive than most and I consider it a very strong drug. I was researching it for personal use before the ozempic craze but it was hard to get dosing and safety data - additionally if I had worrisome complications it would be hard to find a doctor that understood the medication. Now those issues have been fixed. I think more people would benefit from much lower doses for longer - alongside diet and lifestyle changes. Chronic GI issues are definitely something that should be avoided and I think lower dosing helps with that.