The conscious analysis of tone and body language is obviously important for many people to get by socially, especially for neurodiverse people or people outside the norm of the situation. However, I think it is important to avoid remarking directly on body language.
You can still let these non-verbal observations guide a conversation, of course. Rather than remarking on someone's smile when they mention a subject, you might ask them to elaborate on the subject.
Unless they've asked to be psychoanalyzed, most people do not like the feeling of being analyzed.