I don't think the main problem backend developers have with frontend work is the language. As you say, Typescript is a really good language - in many ways better than Python. I don't think it's even the tooling, although becoming basically competent with two very large tooling stacks is not a trivial matter either.

I think there's a fundamental verbosity to the way most SPAs do data management - I've seen it said elsewhere that when you build a SPA, you basically end up having to reinvent the database, by which it is meant that an inordinate amount of your code is dedicated to extracting data from the backend via an API and then keeping track of that state using mountains of front end code.

At some point, you have to decide - is this really two separate applications (a backend and a frontend), or is it actually just one? If you don't have a need for multiple different clients, and you already have a backend written in Python (or some other backend language, e.g. Elixir, Kotlin), then maybe you can get away with writing a whole lot less code if you can find a framework that fills in that whole in-between layer for you and lets you stick with the language you already have.