We work a bit in the space focused on sleep.

My non-medical (I'm not a doctor or scientist) opinion based on my exposure to the controversies and theories I've looked at over the last 4 years is that Alzheimer's is not 1 disease.

Alzheimer's is diagnosed by ruling out other potential issues. Cognitive decline not related to hemorrhages, strokes, thyroid issues, etc get lumped into Alzheimer's (from my understanding).

This theory of the autoimmune system response is interesting, as it suggests why the amyloids exist, but it doesn't necessarily point to them not being part of the issue.