That seems a great idea, and could even be perfected with animal testing before getting near a human. I have no idea if the engineering is good enough yet to precisely hit a rapidly moving target.
Ultrasound is routinely used to break kidney stones. With more precision like this, why not? I don't know if there would be risks though.
Kidney stones flow down a one way river, I'd be worried about a large plaque dislodging and causing an embolism