I used to use PythonCard but it’s been dead for about a decade now. It was inspired by HyperCard and VB, had a GUI designer, and was super simple. It used used wxWidgets for the GUI so it was native looking if you didn’t push it very hard (ie use only basic GUI elements like buttons, menus, and edit boxes).

https://pythoncard.sourceforge.net/walkthrough2.html

This is one of those projects where, if I were retired, I’d love to revive.