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I used to use PythonCard but it’s been dead for about a decade now. It was inspired by HyperCard and VB, had a GUI designer, and was super simple. It used used wxWidgets for the GUI so it was native looking if you didn’t push it very hard (ie use only basic GUI elements like buttons, menus, and edit boxes).

https://pythoncard.sourceforge.net/walkthrough2.html

This is one of those projects where, if I were retired, I’d love to revive.

Decker is well and alive. It does have its own programming language but the effort put into it and the project is astounding.

https://internet-janitor.itch.io/decker

Decker is amazing, and I use it a lot, but the lack of network connectivity is unfortunate and understandable.

QT is probably the closest you'll get, and at that point you might as well just learn cocoa (or whatever the swift version is called these days, i forget)

https://wxwidgets.org/

Qt and wxWindows

Have you looked at SwiftUI?