these types of enclosures are going to be using UAS, USB attached SCSI, which is relatively new. It should deliver a more reliable and manageable experience for external drive enclosures in general (e.g. proper addressing of which drive you want to talk to). If nothing else it's a different code path though.

I've been using a multi-drive UAS enclosure over USB3 as the storage for a VMS for some time, it feels a little weird given USB's history but it has been very reliable and easily saturates the drives from a bandwidth perspective. I'll probably go the same route for bulk storage in the future, since it's a lot easier to get small machines with USB than small machines with 4+ SATA channels.