In terms of serious Mac audio issues, when I got my new M1 MBP I quickly noticed a faint crackling sound (unaffected by the volume setting) in the headphone jack when plugged in via MagSafe or a left side USB port. So I just have it plugged in to power on the right side instead.
Other people have reported it too, so it's not just a one-off defect. I know electrical engineering is hard, but it's a really annoying problem to exist on a super expensive laptop.