I wish I'd never heard of Trulicity or Ozempic. You won't ever be able to come off of it without suffering. I didn't lose weight, but I've gained coming off it.
I was in Ozempic for a few months when I couldn't get Trulicity because of supply issues.
Personally, I see these drugs as a shim until we can fix the biology with gene therapy.
The thing is, there's the main ingredients (semaglutide/liraglutide/exenatide/tirzepatide/...) and also the ingestion mechanism -- like Rybelsus can be taken orally and has a MUCH lower dosage/absorption rate. Only some of them seem to have "extra" side effects (the scariest of which being suicidal thoughts).
https://news.ycombinator.com/item?id=38495653
https://news.ycombinator.com/item?id=39284781 (dopamine signaling that potentially makes GLP-1 agonists anti addictives)
I have a history of seeing some of the worst interpretation of the worst side effects of medication. I'm pretty sure I would have been better off just going ketovore when I first found out I was diabetic in my early 20s... Now I'm nearly 50 and my metabolism is completely broken.
With the gastroparesis, I've got a hard time even keeping the insulin intake correct... I can go a full day without eating hovering around 100… then suddenly my cgm alarm goes off at 240... Sometimes the opposite, it'll be around 150 all day then suddenly drop to 65 and I feel ravenous and thirsty.
Would you mind sharing what dosage you were on? I've been doing quite a bit of research into the effects of these drugs recently for a site I'm working on, and so far that "adverse effect" has basically never been mentioned.
Having more food noise/cravings after getting off the drugs is a terrible side effect.