Boomers Will Define the Ozempic Era | Hacker News Reader

Boomers Will Define the Ozempic Era

theatlantic.com

8 pointspaulpauper9 comments

It's been nearly 4 months since I stopped taking Trulicity because it caused gastroparesis, which is horrible on it's own. Now I'm literally hungry all the time and still haven't returned to normal.

I wish I'd never heard of Trulicity or Ozempic. You won't ever be able to come off of it without suffering. I didn't lose weight, but I've gained coming off it.

I was in Ozempic for a few months when I couldn't get Trulicity because of supply issues.

Did you have any side effects when you were taking Ozempic? Would you go back to Ozempic? Would you consider GLP-1 gene therapy instead?

Personally, I see these drugs as a shim until we can fix the biology with gene therapy.

Sorry if this is a silly question, but goes GLP-1 gene therapy exist yet? I've been doing a ton of fact findin on GLP-1 recently and absolutely have not come across this.

The thing is, there's the main ingredients (semaglutide/liraglutide/exenatide/tirzepatide/...) and also the ingestion mechanism -- like Rybelsus can be taken orally and has a MUCH lower dosage/absorption rate. Only some of them seem to have "extra" side effects (the scariest of which being suicidal thoughts).

There are no silly questions. Stay curious.

https://news.ycombinator.com/item?id=38495653

https://news.ycombinator.com/item?id=39284781 (dopamine signaling that potentially makes GLP-1 agonists anti addictives)

Appreciate the links, going to dig in -- thank you!

I'm not sure... I never really had hunger issues before them... I did gain weight on Ozempic vs Trulicity which everyone thought was weird. I hadn't really changed my eating habits while taking either.

I have a history of seeing some of the worst interpretation of the worst side effects of medication. I'm pretty sure I would have been better off just going ketovore when I first found out I was diabetic in my early 20s... Now I'm nearly 50 and my metabolism is completely broken.

With the gastroparesis, I've got a hard time even keeping the insulin intake correct... I can go a full day without eating hovering around 100… then suddenly my cgm alarm goes off at 240... Sometimes the opposite, it'll be around 150 all day then suddenly drop to 65 and I feel ravenous and thirsty.

Wow this is a really sad experience, that sucks.

Would you mind sharing what dosage you were on? I've been doing quite a bit of research into the effects of these drugs recently for a site I'm working on, and so far that "adverse effect" has basically never been mentioned.

Having more food noise/cravings after getting off the drugs is a terrible side effect.

> Already, seniors make up 26.6 percent of the people who have been prescribed these and other GLP-1 agonists, including Ozempic, since 2018, according to a report from Truveta, which draws data from a large network of health-care systems.

> In the coming years, that proportion could rise even higher: The bipartisan Treat and Reduce Obesity Act, introduced in Congress last July, would allow Medicare to cover drug treatments for obesity among its roughly 50 million Part D enrollees above the age of 65; in principle, about two-fifths of that number would qualify as patients.

TIL, this is a big change that went mostly under the radar (well, my radar at least!).

I have a sneaking suspicion though that once availability goes up and price goes down, we'll see many more than seniors on the drugs.

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