And they were certainly breathing lots of smoke from their cooking fires. Although wood smoke is probably less hazardous than two stroke oil.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810277/
: Scientific evidence has shown that metal ion binding to β-amyloid accelerates amyloid aggregation, which could finally damage the neurons in AD (Pithadia and Lim, 2012). The involvement of copper in AD is controversial, as some studies show copper deficiency in AD, and consequently a need to enhance copper levels (Borchardt et al., 1999; Kessler et al., 2005, 2008a,b; Exley, 2006; Jiao and Yang, 2007; Vural et al., 2010; Kaden et al., 2011; Exley et al., 2012), while other data point to copper overload and therefore a need to reduce copper levels (Cherny et al., 2001; Sparks et al., 2006; Hua et al., 2011; Luo et al., 2011; Ceccom et al., 2012; Eskici and Axelsen, 2012; Brewer, 2014; Squitti et al., 2014b; Yu et al., 2015). An aberrant copper homeostasis with an increase in the labile pool of copper and a decrease in the copper bound to protein is the main up-dated interpretation (Kepp, 2016; Squitti et al., 2016). In this paper, the role of metal ions, particularly copper, in AD is reviewed and discussed.
I spot checked starting from newer to older the too much copper citations and the third one I checked, "Brewer, 2014", though it itself cites animal studies, was about copper in humans (specifically inorganic copper as a hypothesized problem, versus organic copper which he says is fine). The Brewer paper references "Squitti et al., 2005" which was a study of humans showing elevated copper (of inorganic origin? I didn't read further than the abstract) and a couple of other things in Alzheimer's patients.
So copper from food? Good. Copper from water pipes? Bad. Chelated copper from supplements? I don't know. Maybe further reading would show other results. Again, I just skimmed this.
There is literally no reason to believe this. Plus, the amounts leeched from pipes are nowhere near high enough to provide even the paltry RDA. People used to cobsume more. They used to use bronze or copper cookware. It's bullshit. You are only coming up with excuses why it isn't copper. Why? I suppose because the cure would be almost free.
Brewer disagrees (copper from pipes or cookware is inorganic copper).
> You are only coming up with excuses why it isn't copper.
I genuinely don't know. I just found your claim interesting and searched for articles on it. And what I found is conflicting information.
I don't care. It's unreasonable. There is no such a thing as "organic copper". People used to use those much more. There is no good correlation between blood levels and copper status. The actual levels in the actual brains show the opposite in autopsies.