Hi, one of the Unison creators here. We've talked about adding pluggable syntax[1]. It's in principle straightforward (the code is already stored in a database as its abstract syntax tree, not text) and I imagine a future version of Unison could let you pick from a variety of syntaxes. But we haven't gotten to it yet.
[1] https://github.com/unisonweb/unison/issues/499
... that said, the language semantics and libraries are still going to be different, so even if we have a python-ish or typescript-y syntax, there'll still be new things to learn. :)