I think it very much depends on the viewing distance. Using
https://qasimk.io/screen-ppd/:
* Your 22" screen at a distance of 32" has a horizontal FOV of 33°. Moving your eyes from the middle of one screen to the adjacent screen is a 33° movement. Assuming 1080p it would have a PPD of 58, which is roughly retina PPD.
* My 27" screen at a distance of 20" (I measured it [update: originally measured at 14", remeasured in a more relaxed posture]) has a horizontal FOV of 60°, almost twice as wide. Moving my eyes to an adjacent screen would be physically impossible and I'd have to turn my head since the maximum adduction angle for human eyes is ~45° (each side). At 4K it has a PPD of 32, not even retina.
Although you can move your eyes from the center of the left screen to the center of the right (33 * 2 = 66°), you can't see the edges of your outer screens without turning your head slightly (33 * 3 = 99°, greater than human adduction of 45 * 2 = 90°).
Your three screens have a combined FOV of 99°, which is 50% bigger than my single 27" at 60°. That's definitely more, but it's 1.5x, not 3x, more. So our setups are not that different, it's just that you are using three monitors to cover a little more horizontal FOV than I get sitting closer to just one.
> I find it more uncomfortable to eyes to switch screens on the same window, especially if one is light and the other is dark. The blinking is disorientating and can be eye hurting, because eye is not prepared for the color switch/ doesn't know what to expect.
I use dark theme for everything so don't have this issue and am constantly switching between tabs and windows.