Well, this exactly explains why HN's site has become so unreliable for me.
As soon as this post appeared, I began receiving timeouts. 90% of the time, the front page won't load, the host won't respond.
I have no troubles with any other IPv4 or IPv6 sites. My home network has been running IPv6 for about 8 years, since my ISP enabled it and I worked out some good router settings.
I routinely verify that all 3 of my devices are preferring IPv6. These timeouts are not occurring on my Android 11 phone, only on my Chromebook for now. Windows 10 Pro, not tested.