The issue with long runs of 0x00 is related to "clock recovery".
> Some digital data streams, especially high-speed serial data streams (such as the raw stream of data from the magnetic head of a disk drive and serial communication networks such as Ethernet) are sent without an accompanying clock signal. The receiver generates a clock from an approximate frequency reference, and then phase-aligns the clock to the transitions in the data stream with a phase-locked loop (PLL).
> In order for this scheme to work, a data stream must transition frequently enough to correct for any drift in the PLL's oscillator. The limit for how long a clock-recovery unit can operate without a transition is known as its maximum consecutive identical digits (CID) specification.