If you are doing long speaker cable runs and are using 12 gauge wire anyway… At some point it occurs to you, why not just use Romex ?
And, in fact, it’s a very good choice. 12/3 romex - typically used in three Way lighting circuits - gives you two speaker pair in one nice package.
Two downsides:
First, it can be confusing for future electricians, etc., who do not expect romex in the wall to be used for low voltage.
Second, stereo terminal connectors are not typically designed for solid copper and that can get a little frustrating and complicated.
… but then you think about it a little more and it occurs to you:
why not just build terminal blocks and make connections with WAGO lever nuts ?