Perhaps there just isn't enough of a market, but ASRock made a series of nice little machines they called DeskMinis with 5x5in motherboards that were a bit larger than NUCs, but in the extra space could fit a socketed 65W chip and quiet low-profile cooler (NUCs I've used were noisy under load), two full-length NVMe M.2 disks, and two 2.5" SATA drives.
An updated AM5 version could potentially ditch SATA to be smaller, since there isn't a huge premium on NVMe capacity now. I wonder if they could also handle some non-G chips, since those now have very basic iGPUs (though power and/or chipset requirements could still limit that).
One issue is that AM5 is still the relatively expensive option; AMD is still adding new AM4 5xxx SKUs because there's still seemingly a market for them. The DeskMini systems could be economical, and if a similar AM5 system couldn't be, due to the mobo itself needing to be pricy or the 8xxxG + DDR5 SODIMM cost, maybe it's hard to sell enough of them to get it to make sense. Still, it's a fun idea, and if you're listening, ASRock, I can promise you'd sell at least one.